Diagnostic Utility of Procalcitonin and Crp in the Detection of Bacterial Infection in Patients of Abdominal Sepsis

Abstract

Background: Abdominal sepsis presents as systemic inflammatory response of the host to bacterial peritonitis which results due to direct spillage of luminal contents into peritoneum .Postoperative bacterial infections, is a one of the causes of morbidity after abdominal surgery.CRP is an acute phase protein that is released during inflammatory conditions.Standard concentrations of C reactive protein are from 0.8 mg/dl to 3.0 mg/l in healthy individuals. However at 10 mg/l some healthy adults may exhibit elevated C reactive protein levels.CRP levels rise to about 10.000 fold from less than 50 micro gram/litre to more than 500 mg/l when there is stimulus. It doubles every 8 hours peaking 30 to 50 hours after an injury or inflammation. Because of bacterial infection CRPs between 100 and 500 mg/l are considered highly predictive of inflammation.Procalcitonin is a  precursor peptideto the hormone calcitonin.The amount of procalcitonin is below the limit of detection (0.01 microgram/lit) in the bloodstream of healthy individuals . In response to pro inflammatory stimuli which is mostly of bacterial origin , the amount of procalcitonin increases. The procalcitonin induction duration is 4-12 hours with a half-life of 22 to 35 hours . With extreme infection triggered by inflammatory cascade and systemic reaction, the levels of procalcitonin in blood increase, correlating it with severe disease. 

Objectives:

1. To evaluate diagnostic utility of C-reactive Protein in detection of bacterial infection in abdominal sepsis.


2. To evaluate diagnostic utility of procalcitonin in detection of bacterial infection in abdominal sepsis.

Methodology:It will be a prospective study done on the patients affected with acute abdomen. It will be conducted at department of general surgery, JNMC and AVBRH, Sawangi (Meghe), Wardha of DMIMS (DU) .The study will be done on patients affected with acute abdomen.

Results: The result would be undertaken in SPSS software

Conclusion: Conclusion will be based on findings for study of protocol.