The Study Protocol for Evaluation of the Concept of Anupana as Bioavailability Enhancer Effect with Special Reference to SaindhavaLavana along with Haritaki (TerminaliaChebula Retz.)

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Jaydeep Kumar Sahu, Renu Rathi

Abstract

Background:Ayurveda medicines are prescribed to be taken with various media of intakes like warm water, honey, ghee, milk etc. Such substances for taking medicines are called as Anupana. It is also known as vehicle or adjuvant. It may enhance the absorption, action and therapeutic effect of the principal drug.


Objectives: The present study aimed to evaluate the bioenhancer activity ofSaindhavalavana (Rock salt) as aAnupana of Haritaki (Terminaliachebila Retz.).


Material and methods: The present study is a experimental study in which 30 healthy volunteers will be enrolled in two groups. In group A Haritaki (TerminaliachebulaRetz.) fruit Kwatha(Decoction)will administered as control and group B will administered Haritakikwathaalong with Saindhavalavanaas trial. The dose of kwath should be 48 ml and 3gm of Saindhavalavana as Anupana once after breakfast. At a predetermined interval of 0, 30, 60, 90, 120, 180, 240, 300 and 360 min after administration of Haritaki, (2ml) blood will be collected from pre-inserted cannula in the vein and immediately transferred to the EDTA tube. Then blood serum will be collected and analysis will be done. Objective parameters like Phenolic compounds will be assessed through HPLC method. With the help of unpaired t-test using SPSS statistics software and p values less than 0.05 will be noteworthy.


Result and Discussion: Results and observation will be presented in the form of graph, chart and tables with statistical values of significance. The obtained values will be discussed with suitable scientific interpretations.


Conclusion: Suitable conclusion will be drawn from the obtained observation and results.

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How to Cite
Jaydeep Kumar Sahu, Renu Rathi. (2021). The Study Protocol for Evaluation of the Concept of Anupana as Bioavailability Enhancer Effect with Special Reference to SaindhavaLavana along with Haritaki (TerminaliaChebula Retz.). Annals of the Romanian Society for Cell Biology, 3291 - 3299. Retrieved from http://annalsofrscb.ro/index.php/journal/article/view/439
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