Can Proinflammatory Markers like IL6 and TNF Alpha be the early Predictors of Subclinical Peripheral Neuropathy in Prediabetes?

Abstract

Introduction:Polyneuropathy is the commonestcomplication present in almosthalf of the diabetic patients which is related directly with the duration and severity of hyperglycemia. Neuropathy can develop as of in the pre-diabetic phase, as evident from the different studies. The reason for this is the endothelial injury leading to micro inflammation.

Aim and Objectives:We extend our analysis to study the proinflammatory markers IL6 and TNF alpha in the subclinical peripheral neuropathy in prediabetes as biomarkers for the early risk predictors and therapeutic targets for prediabetes and related complications and to study the peripheral neuropathy in prediabetes.

Methods: A cross sectional study which will be carried in the medicine department at Acharya Vinoba  Bhave Rural hospital at Sawangi.The individuals will be screened for prediabetes andaccording to American Diabetic Association i.e. Impaired fasting glucose-100 -125 mg/dl And/ OR   Impaired glucose tolreance-140 - 199 mg/dl. Or HbA1C of5.7% -6.4%   the subjects will be included in the study. Their serum TNF-α and IL-6 levels will be measured by BD CBA Flex capture beads method (B D  BioSciences 2350 Qume Drive San Jose,CA 95131.Nerve Conduction Studieswill be performed using the standardized technique on bilateral tibial and sural nerves in lower limbs with surface recording.

Results: The proinflammatory markers will be raised in the patient who will have subclinical peripheral neuropathy than those who do not have neuropathy in prediabetic subjects.

Conclusion:The study will probably assist us to associate the relation of neuropathy with prediabetes and early intervention of treatment of prediabetes with the help of drugs rather than lifestyle modification.