Main Article Content
In medicinal chemistry, there is a great demand to design, develop, and identify novel drug-like agents with the highest therapeutic potentials and lowest side-effects. Naphthalene moiety was found highly in nature, and many reports have been conducted to extract naphthalene-derived products and investigate their biological activities. Synthetic naphthalene-based compounds have been found to possess potent bioactivities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory, and cytotoxic effects. In the literature, many studies have been investigated the influence of conjugating various aryl- and heteroaryl-derived moieties with naphthalenes on their biological activities. The results of most of these studies revealed that this type of conjugation could improve the bioactivities of the parent naphthalenes. This systematic review summarized the most important and recent examples of such studies and highlighted the structural features of the resultant conjugates to be considered as promising bioactive scaffolds.