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Clinical and etiological spectrum of acute symptomatic seizures in developing countries is different from developed countries. Hence this study was done to know the various etiologies of new onset seizures in adults in this region. 100 Cases of new onset seizures from SreeBalaji medical college and hospital were included in the study. The etiology was determined by appropriate investigations including neuroimaging and cerebrospinal fluid examination. In patients with cerebrovascular diseases, aged under 40 years, cerebral venous thrombosis accounted for 79%. This study illustrates that the etiological spectrum of seizures in this part of the world is different from that described from developed countries and CNS infections account for a significant number of cases.