Associations Between FecalsIgA Level with Neonatal Sepsis

Abstract

IntroductionSepsis is one of the leading causes of infant morbidity and mortality throughout the world. Early diagnosis and accurate treatment of neonatal sepsis is still challenging because as the gold standard, blood culture takes a long time. Secretory IgA (sIgA) holds an important part in mucosal integrity and mucosal homeostasis. Therefore, sIgA level can be considered as a predictor for neonatal sepsis.

Purpose This research is aimed to analyze the associations between fecalsIgAlevel with neonatal sepsis.

Methods This research uses analytic observational design with cross-sectional approach. All infants with suspected sepsis in the NICU of RSUP Prof. Dr. R.D. Kandou Manado from July to August 2019 is included in the study.

Results A total of 41 infants are included in the study, where 21 (51.22%) are confirmed neonatal sepsis. Secretory IgA levels are higher among the non-sepsis infants (1347.59 503.24 g/ml) than their counterparts (461.86 297.28 g/ml) which is statistically significant (P < 0.001) with r_pb = -0,742. This result is also confirmed by logistic regression, with regression coefficient of -0.005 (P < 0.001).

Conclusion There is a significant inverse association between fecalsIgA level and neonatal sepsis.