The Effect of Fenkarole and Zaditen on the Intestinal Microflora of Rats in the Stages of Sensitization and Food Anaphylaxis of Passive Anaphylactic Reaction

Abstract

It is known that the prevalence of allergic diseases is constantly growing in both developed and developing countries. Therefore, changes in the microeubiotic system of the rat intestine in the stages of passive anaphylactic reaction (PAR) and the influence of antihistamines on the observed disorders of intestinal microbiocenosis were studied in this work.

In experiments on white rats, changes in the microflora of the small and large intestine in the stages of sensitization and food anaphylaxis of passive anaphylactic reaction and the effect on the observed disorders of antihistamines fenkarole and zaditen were studied.

Based on the results of experiments, it was found that under the conditions of PAR, the most pronounced dysbiotic changes occurred in the microflora of the small and large intestine on the 6th day of sensitization and on the 3rd day of food anaphylaxis, and relatively more distinct dysbiotic shifts were observed in the large intestine. While studying the effect of antihistamines on these disorders, their ambiguous effect was established, although fenkarole and zaditen did not have a sufficient protective effect on dysbiotic changes in the intestinal microflora.