Uterine leiomyomas (Uterine fibroids)

Abstract

Uterine  fibroids  are  neoplasms  of  the  uterus with  both smooth  muscle  and  fibroblast  constituents,  additionally  to  an amount    of    fibrous    extracellular    matrix.    Fibroids    are   completely different   in   their   pathophysiology,   size, site   and their clinical symptoms.  In spite of the fact that uterine  leiomyomas  represent  a significant public health concern, the causes and pathogenesis of these lesions  not very well    understood.  Fibroids  are usually  associated  with race; seen in black women more than in white one with more-severe forms of the disease.   Symptomatic   fibroids   interfere   with   physical   and   social activities,  affecting  relationships,  employment  and  making  women  feel worn  out  and  sad  or  depressed.  About  one- third  to  half  of  all  hysterectomies    are  fibroids . Treatments     are          surgical     and     interventional.  The  progesterone receptor modulators, such as ulipristal acetate, are used as a medical therapy. There is a new suggestion that the genetic subgroups lead to fibroid formation, aid in the understanding of the clinical heterogeneity of this disease and lead  to individualized treatments. This article will summarize the important information published in recent years about this disease.