Pathological Changes of Visceral Leishmaniasis on Liver and Spleen in Experimentally Infected BALB/C Mice

Abstract

Visceral leishmaniasis is a zoonotic protozoal disease caused by Leishmania donovani in which the pathogen disseminates to visceral organs inside the macrophage that survive within phagolysosome & evade host defense mechanism result in potential fetal infection associated with hepatosplenomegaly, lymphadenopathy and progressive anemia.The present study include study of pathological changes in reticuloendothelial system (liver and spleen ).The result detected Different pathological lesions showed in different passages. Mild pathological changes noticed in liver  in mice of passages one and two associated with granuloma formation with centrilobular necrosis in liver parenchyma, also the liver is disorganized and hypocellularity, with hepatic sinusoidal dilation and congestion with slight  congestion  of hepatic central veins. While in spleen, the pathological changes were mild to moderate suppression in lymphoid tissue of white pulp. The more splenic lesions showed in mice of passages three and four were granuloma formation with presence of amastigotes of Lishmania donavani