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This paper identifies and compares the degree of offensive behaviors, stress, and burnout of nurses in general and special departments.The survey included 542 nurses from 19 general wards and 19 special departments in 6 hospitals in Korea. The differences of stress and burnout by demographic characteristics were measured by t-test and ANOVA. T-test was performed to compare the degree of offensive behaviors, stress, and burnout between the two groups.Offensive behaviors on general departments were significantly higher than for nurses on special departments. Stress and burnout on special departments were significantly higher than for nurses on general departments. The differences in offensive behaviors, stress, and burnout were found in general and special departments.Different strategies between general and special departments are needed at the organizational level, such as compensation schemes and education programs.