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The current work was done to determine the impacts of sub- acute exposure with two doses of nickel nitrate on the body and organs weights, hematologic and some biochemical criteria as well as histological changes of heart, liver and kidney in adult male rabbits. Eighteen rabbits were used and distributed randomly into 3 groups, group one considered as control which was administered 1ml of distilled water orally, group two was administered 10mg/kg of nickel nitrate orally, group three was administered 20mg/kg of nickel nitrate orally. Our findings exhibited that nickel nitrate administration cause to moderate alteration of complete blood count values in rabbits treated with 10mg/kg dose while marked changes were seen in rabbits treated with 20mg/kg dose. The histopathological changes in two dosages of nickel nitrate were notable. In conclusion, it can be concluded from current outcomes that exposure to nickel nitrite causing pronounced adverse effects in the blood and organs ( heart, liver and kidney) that indicating that nickel nitrate is hazard pollutant.