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Rheumatoid arthritis (RA) is a common autoimmune disease and is characterized by chronic inflammation that affects the joints and leads to joints damage and losing their normal functions and chronic pain. Rheumatoid arthritis disease is prevalent worldwide and affects both sexes and all ages. The current study included seventy-five patients positive for rheumatoid factor attending the hospitals and private clinics.This study aims to investigation the correlation between ACCP and development, progression, and activity of RA in Iraqi patients. ACCP was analyzed using ELISA technique,using Sandwich-ELISA method. The results of the study showed that the percentage of women patients is 88% and the rest are males. The most affected age group is between 32-41 years, and its rate is 29%. As well as the results showed the levels of ACCP in rheumatic patients were high than in control group with significant increase in patients (p<0.001). The results also showed that ACCP increased with the progression of disease activity, reaching the highest level of this factor in sever status (p<0.02).Our results conclude the increase of ACCP in serum of RA patients was associated with development and progressionof rheumatoid arthritis in Iraqi patients, while there is no effect of sex, age, or associated diseases on the level of ACCP in patients serum.