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Hydatid cyst disease is a widespread disease that affects both humans and animals. It has a global spread, is an epidemic, and is harmful to human and livestock health. Since there have been few research types on this disease, this study was conducted to determine the histological damage to the liver caused by it and serum concentrations of biomarkers such as ghrelin, p-selectin, and leptin in humans. The current study discovered a connection between hydatid disease and liver histological changes, such as fibrosis, inflammation, and necrosis, compared to a healthy human liver. Furthermore, the findings revealed that serum leptin levels in patients with Hydatid cyst disease were significantly lower (P 0.05) than in the control group and a substantial increase in p-selectin and ghrelin levels in patients relative to the control group.