Synthesis, Identification, Chromatographic Studying of Formazane –Phenylenediamine Derivatives

Abstract

The research included two lines to prepare new derivatives of Formazan of medical and industrial importance, and the preparation carried out according to the following lines: The first line: four formazan derivatives were prepared by coupling the base of the preparation with aromatic amines (P-nitro aniline, O-hydroxy aniline, P-chloro aniline, 4-amino-5-methyl-2-phenyl-1.2-dihydro-3H-pyrozol-3-one) in a basic medium with the azotation step. As for the imine used, it was prepared through the condensation reaction of anthranilic with (o-phenylenediamine) in an acidic medium to form the first amine, which was treated with four types of aldehydes (vanilline, 2-nitro benzaldehyde, o-hydroxy benzaldehyde, p-hydroxybenzaldehyde) to form four new derivatives of the imine compound., The second line: two derivatives of formazan were prepared by reaction of two derivatives of the new imine compounds with two types of amines (P-chloro aniline, benzo imidazole-2-amine) in a basic medium where they were lubricated to accumulate the formazan compounds. As for the new Schiff base compounds, they were prepared from the condensation reaction of anthranilic with (p-phenylene diamine) in the presence of sulfuric acid (H2SO4) to form the first amines, which were treated with two types of aldehydes (vanilline P-nitro benzaldehyde,) to form Schiff bases. Each reaction is followed by TLC technology as well as measurement of the melting point of the prepared compounds. Study the chromatographic behavior of the prepared compounds. All compounds prepared were identified using different chemical techniques, such as (1H.NMR spectra, ¹³C.NMR-spectra, FT.IR-spectra), melting points and physical properties.