Evaluation of the Combined Effect Onethanolic Extracts of Pisoniagrandis and Cardiospermumhalicacabum Inanti-Arthritic, Anti-Inflammatory and Analgesic Activities

Abstract

            In India, several plant species are utilized as a medicine for pain & arthritis condition. Various human disorders predominantly arthritic condition causes inflammation and pain as nonspecific symptoms. Pain is an uncommon mechanism which is caused by inflamed cells or tissues. Many plant-based medicines with analgesic and anti-inflammatory properties have been used for a long time with no negative side effects when comparing to synthetic drugs with same properties. The aim of this study is to evaluate the anti-inflammatory, anti-arthritic and analgesic properties of BHE which contain equal amount of Pisoniagrandis and Cardiospermumhalicacabum leaves with ethanolic extract extracts of Pisoniagrandis (EPG) and Cardiospermumhalicacabum (ECH). Analgesic activities of plant extract were measured by thermal methods such as hot plate, tail flick method along with chemical method of acetic acid writhing. The anti-arthritic and anti-inflammatory potential of BHE, EPG and ECH was evaluated by formalin induced acute non –immunological arthritis model as well as turpentine oil andcarrageenan induced paw edema in rats. The BHE showed a substantial (p<0.01) reduction in paw volume and edema when compared to EPG and ECH. The Hot plate, Tail flicking, and acetic acid writhing methods all showed the same effect, suggesting that BHE has potential central and peripheral analgesic activity.BHE, which is made up of two herbal plants, has anti-arthritic, anti-inflammatory, and analgesic properties that promote its traditional use by reducing the immunological and inflammatory reactions seen in most arthritic conditions.