In Vitro Analysis of Neuroprotective and Antioxidant Property of Sponge Extract

Abstract

Neurodegeneration is a progressive loss of structural and functional properties which finally leads to death of neurons. The accumulation of high concentration of the reactive oxygen species (ROS) in brain cells leads to damage and apoptosis which finally leads to the neurodegenerative disorders like Alzheimer (AD), Parkinson (PD) and Huntington disease etc., thus neuroprotective activity plays an important role in brain, working as a defensive mechanism which can either be self-developed or can be obtained through medication. Natural marine products are a rich source of novel compounds that can alter mammalian neurological activity. Marine sponges are one of the most sustainable and efficient sources to explore when bio-prospecting for neuroprotective compounds that can play a vital role in medicine. The sponge protein from Callyspongia sp. was extracted using β- mercaptoethanol and triton X-100 method. The main aim of the study is to unravel that the extract form Callyspongia sp. exhibits an excellent wound healing activity and cell viability in L929cell lines.