Development and Evaluation of Polyvinyl Alcohol Gel of Indomethacin by Nanosuspension and Β-Cyclodextrin Technique

Abstract

Indomethacin from a class of NSAID drugs used to relieve pain, swelling, and joint stiffness. It is a class II drugs which have low water solubility. This study was aimed to investigate the solubility and permeability of Indomethacin in two different techniques such as nanosuspension and β-cyclodextrin. Nanosuspension are submicron colloidal dispersions that increase dissolution rate and diffusion of drug into the skin. B-cyclodextrin is a hydrophobic interior and hydrophilic exterior, complexes formed with hydrophobic compounds. To compare the solubility and permeability of the different gels. Two gels were formulated in a different way, for nanosuspension Indomethacin was dissolved in ethyl acetate and the solution was heated to 80 ⁰C and allowed to evaporate. β-cyclodextrin was prepared by kneading technique 2:1 (β-CD: Indomethacin) molar ratio. Wetted with drops of methanol and allowed to dry. The gels were kept in cold room to maintain its stability. The formulated gels were evaluated for various physio-chemical evaluation tests such as solubility studies, pH, Franz diffusion and physiochemical evaluation. All other basic materials needed for gel preparation were used. The gel formulated in β-cyclodextrin showed a higher solubility (0.999) absorbance than nanosuspension (0.437) but nanosuspension showed a higher permeability in releasing the drug over 6 hours (23.13%) but in the same duration B – cyclodextrin releases 9.38% of Indomethacin across the membrane.β-cyclodextrin is more soluble in water whereas nanosuspension has a higher permeability that diffuse across the membrane. nanosuspension formulation proved to have a higher pharmacological effect.