Immunological Aspects of the Pathogenesis of Chronic HCV Infection

Abstract

Today, it is known that cytokines secreted by immune cells are critical in cell-mediated and humoral immune responses, as well as in antiviral activity, viral clearance, apoptosis, and fibrogenesis. A review of the literature has shown that the level of production of many cytokines is associated with the severity of LC and viral etiology of LC. An in-depth study of immunopathogenesis will make it possible to clarify the mechanisms of inadequate immune response in HCV infection, which will contribute to the diagnosis, prognosis of the course of these diseases and the choice of adequate therapy.