Comparitive Study of Epidural Fentanyl and Bupivacaine with Epidural Clonidine and Bupivacaine for Post Operative Pain Relief in Lower Abdominal and Lower Limb Surgeries- A Randomised Controlled Trial

Abstract

This study was undertaken to chart and find out analgesic total time duration including the sedation and side effects of Bupivacaine (0.25%) with Fentanyl 2μg/ml and Bupivacaine (0.25%) with Clonidine 2μg/ml given via epidural route in patients post operatively who underwent lower abdominal and lower limb surgery under spinal anaesthesia.The present study includes the addition of Clonidine to 0.25% bupivacaine significantly prolonged the duration of post-operative analgesia with adding Clonidine was found to be prolonging the time duration for First Rescue Analgesia.This study focuses on the addition  of  Clonidine  epidurally produced  sedation that was easily  arousable for many hours compared to Fentanyl and Occurence of adverse effects such as hypotension were found to be more in patients who got clonidine, this was not statistically significant between the groups. No episode of respiratory depression was noted in both the study groups which are more common with opioids. With regard to acceptance, the patients who received Fentanyl were highly satisfied by the study drug administration.