Cytokine Storm Magnifies the Mortality Rate in COVID-19 - A review

Abstract

The knowledge on the association between cytokine storm and CoViD-19 helps in effective treatment planning. With this background, the present review highlights the association between cytokine storm and CoViD-19 and the effective treatment planning options.The number of articles used in the present study is around 50 - 60 articles. These articles are collected from various search engines like Google Scholar, PubMed, MeSH core, MedRxiv, Cochrane, BioRxiv. Also, two primary Chinese databases for Biomedical Research purposes which includes CNKI and WanFang were used as a source for articles in this study. The relevant articles were collected from the period of 2000 to 2020 (till date). The article collection involves five steps.Cytokine storm is an excessive immune response which mediates the Pathogenesis CoViD 19 and increases the death rate. Cytokine storm is the major cause for  Acute Respiratory Distress Syndrome and progresses further leading to death.Cytokine storm has to be managed at an inappropriate time to prevent the magnification of mortality. The control of the cytokine storm in the early stages through immunomodulators and cytokine antagonists is the main therapeutic option which increases the success rate and reduces the mortality rate of CoViD-19 infection. From this review study, we can see that there is a strong association between cytokine storm and CoViD-19 infection.