Synthesis and Characterization some Imidazolidine Derivatives and Study the Biological Activity

Abstract

This paper includes synthesis imidazolidine derivatives (five membered ring) derived from 4-aminoacetophenone and 2-naphthol by multistep reaction, the first step synthesis of azo derivative by the reaction between 4-aminoacetophenone and 2-napthol,after that synthesis shiff bases derivatives (S₁,S₂,S₃), by the reaction between azo derivative (A) with amine derivative (4-bromo,, 4-nitro and 4-chloro aniline), shiff bases derivatives used to prepare some new heterocyclic compounds (five membered ring) by the reaction between the shiff base derivatives (S₁,S₂,S₃) with amino acid (Glycine and Alanine) to prepare imidazolidine derivatives (M₁-M₆). The prepared compounds were characterized by FT-IR, some compound characterized by H¹NMR, ¹³CNMR.All the prepared compounds were studied for antibacterial activity.