Plasma Fibronectin Concentrations for Prognosis of Preterm Delivery: A Cross-Sectional Study in Wasit City, Iraq

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Ibtihal N. Abd Alameer, Muhamed Ali Al Kabe

Abstract

Preterm delivery is the most prevalent cause of fetus mortality and has considerable social and psychological effects for the family as well as the society. Sometimes, the reasons of preterm delivery are unknown. The influential factors, their prediction and prevention are not profoundly realized. Recognizing women who are at risk of preterm delivery is the first effective step in preventing preterm birth. We aimed to determine the diagnostic value of plasma concentration of fibronectin in diagnosing preterm delivery.This is a cross-sectional study which was carried out in the labor facilities in local hospital in Wasit.Therefore, if screening for fibronectin levels using the Enzyme-Linked Immunosorbent Assay (ELISA) test can be carried out in the last trimester of pregnancy, there is a high possibility that Preterm delivery can be prevented.A total 90 blood samples were collected by phlebotomists from patients inPretermand Full-termlabor. We carried our study on 90 pregnant women, divided into two groups. First group delivered preterm 45 and other group 45 at full term.


It was found that patients with preterm delivery had significantly a higher fibronectin concentration than those with full-term delivery (P-value< 0.001).The mean ± SD for preterm pregnancy patients was 77.58±9.06 while it was 50.16±5.38 for full-term. Based on ROC diagram, the best cutoff point of fibronectin concentration that appeared to differentiate those women who delivered earlier than others is found to be equal to or above 62.42 with a significant P-value less than 0.001. The AUC: Area Under Curve; CI: Confidence Intervals, sensitivity, specificity, positive predicting value, and negative predicting value for this test were 0.999, 0.995-1.000, 97.8%,100%,100%, 97.8%, respectively. It was concluded that Fibronectin plasma level in women with preterm delivery was significantly higher than those with term delivery.

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How to Cite
Ibtihal N. Abd Alameer. (2024). Plasma Fibronectin Concentrations for Prognosis of Preterm Delivery: A Cross-Sectional Study in Wasit City, Iraq. Annals of the Romanian Society for Cell Biology, 28(01), 294–304. Retrieved from http://annalsofrscb.ro/index.php/journal/article/view/11846
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