Human Immunodeficiency Virus (HIV): Genomics and Proteomics Knowledge Makes Anti-Retroviral Therapy (ART) More Effective and Successful
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Abstract
Although about 35 million people worldwide are infected with HIV, yet a widely applicable and affordable cure strategy has remained elusive. However, in recent times, using tools of genomics and proteomics we have not only gained better insights of HIV pathology, host interactions both at a molecular and immunological level. These in depth studies, have suggested better drug targets, that have in turn, after extensive clinical trials tested and led to newer drugs achieving better disease management strategies. In this paper, we have described in detail the virology, natural history of HIV, HIV pathogenesis, global epidemiology some of the recent developments in identification of newer drug targets, some success stories, etc. We have also discussed their relevance to the global HIV pandemic and public health challenges in different settings.