Evaluation of Renal and Hepatic Function in Stressed Male Mice

Abstract

The current study of the evaluation of renal and hepatic function of male mice exposed to the stressed environment condition has been carried out in the animal house at the College of Veterinary Medicine University of Wasit. In the experiment design, twenty-four male mice have been divided into three groups: the control group drenched normal saline, the stressed group drenched normal saline and kept at 32±1 for 3 weeks, and the thymoquinone group drenched thymquinone 25 mg/kg b.w. for 3 weeks and kept at 32±1. The result showed a significant effect of thymoqunone on hepatic and renal function compared with control. After 24 hours of thymoquinone administration, synthesized mice with kitamine 100 mg/kg b.w. and xylazine 10 mg/kg b.w. serum collected from centrifuged blood to estimate serum (MDA, GPx, ALT, AST) and took kidney sample for histopathological examination.