Biochemical changes in thalassemia patients infected with Toxoplasma gondii

Abstract

The current study aimed to determine the prevalence rate of Toxoplasma gondii infection in Betathalassemia Major Patients and detection the effect of toxoplasmosis on biochemical changes in patients, in Wasit province. Serum samples from two groups were patients (175 people with beta-thalassemia) and control (35 healthy individuals), were obtained and used to test for anti T. gondii (IgM and IgG) antibodies using the ELISA technique. Then, in T. gondii seropositive patients and controls, the levels of (T3,T4, TSH) were determined using the Mini Vidas technology and urea, creatinine, ALP, ALT, AST using the Cobas c111 technique.  According to the findings, the patient had the percentages of anti-T. gondii IgM and IgG antibodies were 2.28% and 10.85%, respectively. Additionally, the concentrations of T3, T4, TSH, urea, creatinine, ALP, ALT and AST respectively in T. gondii seropositive patients were 2.15 mlU/ml, 101.27 nmol/L, 4.70 µIU/ml, 23.95 mg/dL, 0.37 mg/dL, 181.22U/L, 40.18U/L and 48.73U/L; while in control, they were 9.72 mlU/ml, 11.14 nmol/L, 7.17 µIU/ml, 4.40 mg/dL,-20.13 mg/dL, 9.47 U/L, 0.15U/L and 1.30U/L. In conclusion, statistical analysis results suggest that high significant differences between patients and control individuals.