Correlation of Serum Alanine Aminotransferase, Aspartate Aminotransferase and Total Protein with Copper in Anemic Women

Abstract

Anemia remains a major public health problem, affecting one third of all adults and almost two billion people worldwide. Main aim of this study is to determine serum copper, alanine aminotransferase (ALT),  aspartate aminotransferase (AST) and total protein and explore the possible association that might present between them in Anemic Women.

        Fifty subjects were included in this study, they were divided into two groups; controls group which involved 20 females, and patients group involved 30 females, the sample collection has been attended the students of the college of applied science and some private laboratories in Al-Fallujah city, for the sampling period was from January 2022 to April 2022 and the ages of all subjects was ranged from 20-45 year. Serum levels of Copper  and liver enzymes mentioned in the study were estimated by color enzymatic methods .

       The results showed lower serum levels of Copper (µg/dL) with significant differences in anemic women (P < 0.0001) than in control group. The serum levels of ALT (U/L) was significantly higher in controls (P < 0.0001) in comparison with patients, also the serum levels of, AST was significantly higher  in controls than patients (P < 0.001), while the serum levels of total protein decreased slightly in the patients group in comparison to the controls group (P < 0.001).

      The current study showed that the correlation for Copper with Age weak positive (r = 0.383), (p=0.037), and  negative correlation was notice  with total protein (r = -0.505) (p=0.004) .In addition to no correlation was observed between Copper with ALT and AST.