Validated Method Development for Simultaneous Estimation of Ramipril and Telmisartan in Tablet Dosage form by UV-spectroscopy

Abstract

Two simple, accurate, sensitive and specific methods are developed for the simultaneous determination of Ramipril and Telmisartan in binary mixture. The method based on UV-spectrophotometric determination of two drugs, Method A is by using multicomponant method. It involves absorbance measurement at 205.0 nm(λmax of Ramipril) and 291.0 nm (λmax of Telmisartan) in 0.2M H₂SO₄;. Beer’s law is obeyed in the concentration range of 5-40 μg mL^-1 for Ramipril and 2-20 μg mL^-1 for Telmisartan. Method B is graphical absorbance method which is based on measurement of absorbance of Ramipril and Telmisartan at 222.0nm (iso-absorptive point of Ramipril and Telmisartan) and 291.0 nm (λmax of Telmisartan) Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.