Formulation and Evaluation Acamprosate Calcium to Improve the Bioavailability and Dissolution Profiles

Abstract

Acamprosate (APC) is believed to stabilize the chemical balance in the brain by blocking glutaminergic N-methyl-D-aspartate receptors and activating the gamma-aminobutyric acid type A receptors. Acamprosate is a compound with high solubility and low permeability, BCS - Class III, are not considered highly permeable, they may have site-specific absorption, and so there are a greater number of mechanisms through which excipients can affect their absorption. In the current research the active excipients used in formulations have been shown to alter the bioavailability of BCS Class III drugs APC. The present research work was aimed to develop APC-gastro resistant tablets by gastro resistant method to match the dissolution profile with reference product. The following variables were studied in the research manufacturing process, qualitative and quantitative composition. Various formulations have been studied for APC-gastro resistant tablets’ the reproducibility trial was been taken and confirms that the composition and manufacturing process found to be robust in terms of manufacturing the APC-gastro resistant tablets.