In Vivo Antifungal Activity of Nano-Ointment of Usnic Acid Graphene Conjugates against Candida Albicans

Abstract

Due to its targeted delivery, enhanced skin permeability, and controlled release for the treatment of skin infections, nanoparticle-based formulations have been gaining popularity. The water soluble base was used to generate the nano-ointment of grapheme conjugate with usnic acid, which was then tested for antifungal activity using the fungus Candida albicans. The in-vivo antifungal activity is significant (p 0.001) and comparable to the activity of commercially available standard preparations. This important antifungal feature demonstrates the medication and carrier's synergistic interaction, which was previously documented for their anti-microbial property.