Effect of Interleukin (IL-1B) Gene Polymorphism with the Development of H. Pylori Infection and Treatment Efficiency in Iraq

Abstract

There are numerous transcription factors and cytoplasmic signals that influence the expression of the IL-1B gene and its translation into protein. As a result, there are three key processes in the development and release of IL-1B, which include: Bioactive pro-IL-1B is produced in (I). caspase-1 cleaves pro-IL-1B, resulting in the physiologically active mature version of IL-1B. (III) The maturation of IL-1B and its release. Therefore, caspase-1 is critical to the processing of pro-IL-1B and the quick release of mature IL-1B from the cell. However, the process of secretion is still a bit of an open question. There are various ways in which IL-1B can be secreted and these cannot be mutually exclusive, but each of them can contribute to IL-1B-dependent inflammation in unique and distinct ways.