Neurobehavioral Effects and Oxidative Stress Regeneration By Exirel Pesticide After Low Dose Exposer In Wistarrats

Abstract

Exirel is a second generationanthranilicdiamide insecticide that has biological efficacy against insect pests and can induce the formation of reactive oxygen species (ROS). The main objective of this research is to study the neurotoxicity of an environmental contaminant in albino rats, after Exirel exposure to five concentrations (0.025 mg/kg/d, 0.05 mg/kg/d, 0.075 mg/kg/d, 0.1 mg/kg/d) of oral body weight for 90 days, To our knowledge, this is the first directed study to evaluate oxidative stress in rats white Rattusrattus of the strain Wistar cause by Exirel.From our results the Exirel induced oxidative damage characterized by a very highly significant decrease in glutathione level (GSH), and the activity of glutathione peroxidase, and catalase in the brain compared to controls, on the other hand we observed an increase in the enzymatic activity of glutathione s‐transferase (GST), the MDA level was used as a measure of lipid peroxidation (LPO) in a dose-dependent manner. Behavioral studies containing Classical Open Field Labyrinth and Object Recognition test, we recorded changes in the psychic behavior of rats that manifested themselves in anxiety, disruption of memory and learning disturbances at the level of acetylcholinesterase (AchE) brain, We results showed that exposure to Exirel induced damage and stress in rats.