Study of the effects of NCI667916 and NCI201725 on the invasion and migration of U87 cell line
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Abstract
invasion and migration of glioblastoma U87 cells using 3Dspheroid invasion model and 2D scratch migration model.
The method involves the use of two famous tumor dissemination assays including the 3D invasion spherical model and the 2D scratch model using the U87 glioblastoma cells
The results showed inhibitory effects of both compounds compared to the control on the invasion and migration of the U87 cells in both the 3D invasion model and the 2D migration model.
The compounds NCI667916 and NCI201725 have shown positive inhibitory effects on the invasion of U87 spheres in 3D collagen invasion assay and in the 2D scratch migration assay.
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Manar Zraikat, Walhan Alshaer, Tasneem Alshelleh, Ahmed M Sada Alhanjori, Diala Walid Abu-Hassan, Ghada O Tuffaha, Mutasem Taha. (2021). Study of the effects of NCI667916 and NCI201725 on the invasion and migration of U87 cell line. Annals of the Romanian Society for Cell Biology, 25(6), 20494–20509. Retrieved from http://annalsofrscb.ro/index.php/journal/article/view/10154
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