A Hepatoprotective Influence of Ecdisten Under Conditions of Alcohol Intoxication In Rats

Abstract

The preparation of ecdisten, created on the basis of a natural compound – the phytoecdysteroid ecdysterone, isolated from Rhaponticum carthamoides and Ajuga turkestanica, has been tested as a hepatoprotective agent in rats with alcohol intoxication. It was found that ecdisten effectively eliminates the symptoms of hepatocyte cytolysis and cholestasis, normalizes the glycogen-synthesizing function of the liver, maintains homeostasis of energy production, reduces hypoproteinemia, inhibits lipid peroxidation, inhibits liver fatty degeneration, and has a beneficial effect on the ratio of phospholipid fractions. Ecdisten normalizes bile secretion processes in conditions of alcoholic hepatitis, optimizes the chemical composition of bile.