A Review on Therapeutic Use of Withania Somnifera (Ashwagandha)

Abstract

Withania somnifera (Ashwagandha) is a highly esteemed medicine of the Indian Ayurvedic medicine system as Rasayana (tonic). It is used in a variety of disease procedures and especially as a tonic for nervine. Based on these facts many scientific studies were conducted and its apoptogenic / anti-stress activities were studied in detail. In experimental models it increases the rats' strength during endurance testing and inhibits changes in the adrenal gland of ascorbic acid and the cortisol content produced by swimming pressure. Preparations with Withania somnifera (WS) have shown significant protection against stomach ulcers caused by stress. WS has anti-tumor effect on Chinese Hamster Ovary (CHO) cell carcinoma. It has also been found to be effective against urethane-induced lung-adenoma in mice. In some cases of uterine fibroids, dermatosarcoma, long-term treatment with WS controls the condition. It has a Cognitive Impact Effect and has been helpful for children with memory impairment and aging. It has also been found to be effective in non-neurodegenerative diseases such as Parkinson's, Huntington's and Alzeimer's diseases. It has an imitation effect of GABA and has been shown to promote the formation of dendrites. It has a stressful effect and improves energy levels and mitochondrial health. An anti-inflammatory and anti-arthritic agent and found to be effective in the treatment of Rheumatoid and Osteoarthritis. Extensive studies are needed to prove its clinical effectiveness in stress-related disorders, neuronal disorders and cancer.