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Escherichia coli is one of the main etiological agents of urinary tract infections and its treatment has become more complicated over the years due to the emergence of resistant strains such as BLEE producers. The objective of this research was to determine the level of resistance of extended-spectrum beta-lactamase (BLEE)-producing Escherichia coli to ciprofloxacin in patients with urinary tract infections who attended the Medical Clinic service of the General Hospital of San Lorenzo, perod 2017-2018. The methodology used was the review of 1017 medical records corresponding to the period 2017-2018 of which 353 positive urine cultures were included and microbial susceptibility testing was performed. The results showed that the most frequently isolated microorganism in the two years was Escherichia coli 35% (year 2017) and 36% (year 2018), of the total Escherichia coli strains isolated 40% were BLEE-producing in 2017 and 35% in 2018. In BLEE-producing Escherichia coli resistance to ciprofloxacin was observed 83% in 2017 and 87% in 2018, non BLEE-producing strains a lower resistance of 33% and 60% in 2017 and 2018 respectively, resistance according to sex was 40% for female sex and 60% for male in 2017, while in 2018 presented higher resistance female sex being the same of 86% and in male sex of 14%. Greater resistance was observed in ages between 70 to 79 years for 2017 and between 60 to 69 years in 2018.