Effect of Potassium Bromate on Some Hematological and Biochemical Parameters and Protective Role of Vitamin C on Laboratory Rats (Rattus_Rattus)

Abstract

This study was conducted to investigate the toxic effect of potassium bromate on Wistaralbino rats; twenty-four rats were used in this study and divided into four groups. Each group consistsof six animals.First group the control G: which treated with (0.1)ml from normal saline orally for 21days, second group: treated with potassium bromate 200mg\kg b.w orally for 21 days, third group:treated with vitamin C 400mg\kg b.w which given intraperitoneal (I.P.) for 21 day and fourth group,first treated with potassium bromate and after one hr treated with vitamin C also four 21 days, theresults showed a significant decrease in all blood parameters(R.B.C.s, WBCs, Hb and PCV)in thegroup which treated with potassium bromate as compared with control and vitamin C group. Also,showed a significant decrease in total protein and a substantial increase in the liver enzyme (A.L.T.and A.S.T.) when treated animal with potassium bromate as compared with the control group, andfrom the results can be seen the vital role of vitamin C in return the blood and biochemical parametersforaveragelevel.