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The aim of this study is to review the role Amphotericin B in the treatment of black fungus . At present the world is dealing with the coronavirus pandemic which has completely changed the way of living for us . In the concealment of the current pandemic other diseases are also wreaking havoc on mankind . One such disease is Black Fungus infection which affects people with low immunity .For treating this infection Amphotericin B , an antifungal drug is given intravenously.It is one of the oldest yet most efficient antifungal drug. Amphotericin B has shown good results in treating the infection . In this study we will study about how Amphotericin B helps in curing the Black fungus infection , its mode of action , medical uses , pharmacokinetic properties , synthesis , side effects and possible drug interactions . Currently , Amphotericin B is drug of choice for treating the infection . However , its usefulness is limited because of its severe side effects. This review gives us the brief insight on Amphotericin and its effects on Black Fungus infection.