Evaluation Of Rankl And Opg Levels In Orthodontic Patients Treated With Andwithout Micro-Osteoperforation- A Randomized Controlled Trial

Abstract

OBJECTIVE: The present study aimed to evaluate and compare the levels of RANKL and OPG in orthodontic patients with and without micro-osteoperforation. MATERIALS AND METHODS: Twenty subjects of either sex in the adolescent to adult age group (18-30 years) who seek orthodontic treatment were randomly divided into two groups. Group I consisted of ten subjects for whom micro-osteoperforation was done before the commencement of enmasse retraction. Group II consisted of ten subjects without micro-osteoperforation procedure. GCF samples were collected distal to the canines/first premolars in both groups at four different time intervals namely T0- before the start of retraction, T1- 1^st day of retraction, T2- 45^th day of retraction and T3- 90th day of retraction. Samples were analyzed for the levels of RANKL and OPG. RESULTS: RANKL levels were found to be increased at T1 and T2 but reduced at T3. The levels of OPG was reduced at T1, then increased at T2 and further increase at T3. The OPG/RANKL ratio was the highest at T1 with reduction of the ratio at T2 and failing down further at T3. CONCLUSION: RANKL levels was increased in the experimental group and continued to remain raised till 45 days of retraction and met a decline at 90 days of retraction. OPG levels reduced after 1 day of retraction later followed by a gradual rise up to 90 days of retraction. Thus, MOPs need to be performed at regular intervals in order to maintain the higher levels of RANKL to accelerate tooth movement