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Dental plaque adheres to the numerous hard surfaces in the mouth and is extremely difficult to remove just by rinsing. The complex plaque structure is responsible for a variety of periodontal illnesses, so plaque removal should be done on a regular basis to maintain proper dental hygiene. The cornerstone for disrupting plaque accumulation is mechanical debridement.In individuals with severe periodontal disease, chemical plaque control treatments can be used as a supplement to mechanical plaque control. This article will examine the various chemical plaque control agents and their applications.