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Periodontal regeneration is an age-old notion that is improving with the use of newer and modified barrier membranes to get better clinical results. The placental amnion and chorion membranes are examples of such membranes. It was first used because of its biocompatibility and capacity to facilitate wound healing.The membrane has been utilized in periodontology to help minimise probing pocket depth, boost clinical attachment levels, and stimulate bone formation as part of guided tissue regeneration and guided bone regeneration. These membranes are biologic membranes, which means they are bioresorbable and tissue compatible.Intrabony defects, guided bone regeneration, and root covering procedures have all been treated with it. The clinical implications, literature evaluation, and features of this membrane that make it unique and favourable for use in periodontal regeneration therapy will be reviewed and highlighted in this article.