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Background: The "Coronavirus Disease 2019" (COVID-19) that produced by "Severe Acute Respiratory Syndrome- Coronavirus -2" (SARS-CoV-2) is emergent as a major worldwide communicable disease epidemicObjectives: To determine the level of attitudes and practices of health care workers regarding covid-19 in Mosul city. Subjects and Methods: A descriptive; cross sectional study performed at 28 hospitals and health care centers randomly selected (multistage sampling) in Mosul city, included 517 health care workers. Resultsof demographic data of HCWs: the age range was between 22 -63 years, The Mean±SD of the ages was 39.5±9.9, the highest percentage of ages (38.9%) that was in the age group 30-39 years and the lowest percentage (16.2%) was in the group 20-29 years. The percentage of male in a sample was (52.8%), and females was (47.2%). Regarding educational qualification, the highest percentage (46.8%) was from diploma, whereas the lowest percentage (18.8%) was from secondary school. Regarding occupational level, the majority of studied sample was from Paramedical staff (44.5%). Regarding years of experience, the highest percentage (61.5%)was for those who had equal or greater than 11 years of experience. The most sample of HCWs (82.8%) was married.Conclusion, this study concluded that the highest proportion of the study sample had a good score of attitudes and practices regardingCOVID-19 in Mosul city during the period of study. Recommendation: Establish training programs for HCWs about correct practices in prevention of COVID-19 pandemic by health institutions.