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The association of pathogenic bacteria with a susceptible host is thought to cause periodontal diseases. The primary goal of periodontal disease treatment is to achieve a high level of oral hygiene. Chemical agents can be considered for professional and individual maintenance of oral hygiene. A chemotherapeutic agent is a chemical that is used for therapeutic purposes and is also beneficial to inhibit or kill microorganisms during initial healing phase. Antimicrobials can be locally or systemically delivered. Complementing mechanical therapy with local or systemic antimicrobial therapy can improve treatment effectiveness and thus be beneficial.