Assessment of Adverse Drug Reactions in the Diagnosed ADR Patients

Abstract

Background: Drug-related problems (DRP), including adverse drug reactions (ADRs), constitute a significant health- and quality problem. The present study was conducted to assess adverse drug reactions in the diagnosed ADR patients.

Material and methods: This cross sectional study was conducted to assess adverse drug reactions in the diagnosed ADR patients over a period of 4 months. Before the commencement of the study ethical approval was taken from the Ethical Committee of the institute. The sample size included was 220 retrospective inpatient treatment sheets. Treatment records of individual cases containing clinical diagnosis were considered as sample. From those records, data was collected. The treatment records of the diagnosed case of ADR in the register were initially identified and documented in ADR review form.  The recorded data was compiled and data analysis was done.

Results: In this cross-sectional study a sample of 220 patients were taken. The classes of drugs causing adverse reactions in order of their frequency were drugs acting on cardiovascular system (28.18%), anti-TB drugs (21.81%), NSAIDs(14.54%). A large number of those ADRs were in the form of cutaneous reactions 51.81%. Hepatobiliary (20%) were the second most common ADR. The large proportions of ADRs 55.90% to be mild type while 31.81% of the reactions are of moderate type and 12.27% severe type of reaction. The large fractions of ADRs fall on Type A (Augmented reactions) (81.36%) category of ADRs.

Conclusion:The present study concluded that maximum adverse reactions were caused by drugs acting on cardiovascular system. A large number of those ADRs were in the form of cutaneous reactions and to be mild type. The large fractions of ADRs fall on Type A (Augmented reactions) category of ADRs.