Irisin Level in the Serum of Patients with Psoriasis and its Correlation with Adiponectin Level and the Clinical Severity

Abstract

Background: Psoriasis is a common chronic immune mediated papulosquamous disease that affects 2-3% of the population. The exact cause of psoriasis is still unclear, but it is considered a disease of dysregulated inflammation. Irisin is a novel myokine which is induced by exercise. It is considered as an acute phase protein and marker of inflammation in psoriasis, as irisin level positively correlated with c reactive protein (CRP) levels and sedimentation rate (SR) in psoriatic patients.The aim of this work was to estimate the serum level of Irisin by ELISA and detect its correlation with thepsoriatic activity.Methods: the study was carried outon one hundred subjects divided into two groups: groupI included 50 psoriatic patients and group II included 50 healthy subjects. All patients were subjected to the followings: full medical history, complete general examination, and Proper dermatologic examination.Psoriasis severity was classified according to psoriatic area and severity index (PASI) score. Serum level of irisin was determined by ELISA for both groups.Results: the results revealed that the psoriasis group had significantly higher level of irisin than the control group and there was a significant positive correlation with PASI score (p 0.002*). The sensitivity of irisin in diagnosis of psoriasis was 84%, specificity was 44% and accuracy was 64%. Conclusion:Irisin measurement in the serum of patients with psoriasis provides a tool for monitoring disease activity and can be used as a marker forpsoriasis severity.