Role of C - reactive protein, Serum Ferritin and D-Dimer in Covid Cases: Systematic Review & Meta Analysis

Abstract

Introduction: Patients severely ill with coronavirus disease-2019 (COVID-19) showed hyperinflammation, and the associated biomarkers may be beneficial for risk stratification. We investigated the association between several biomarkers, including serum C-reactive protein (CRP), D-dimer, serum ferritin, and the COVID-19 severity. Methods: We conducted an online search for the COVID patients with the included lab reports and severity. The outcome of interest for this study was the composite poor outcome, which comprises mortality, acute respiratory distress syndrome, need for care in an intensive care unit, and severe COVID-19. Results: A total of 5351 patients were pooled from 25 studies. Elevated CRP, D-dimer, ferritin was associated with an increased composite poor outcome, with an association of the mortality and the severity at various levels. Conclusion: CRP, D-dimer, and ferritin were associated with a poor outcome in COVID-19.