Study the Levels of Galectin-1 in Sera Samples of Patients Undergone to Elective PCI

Abstract

Background and aims:Coronary Heart Disease is a pathological disorder marked by the deposition of atherosclerotic plaque in the epicardial arteries, whether obstructive or non-obstructive.Percutaeonus Coronary Interventionis a non-operative procedure used to treat stenosis of the coronary arteries of the heart seen in patients with coronary artery disease.In the early stages of Acute Myocardial Infarction (AMI) in vivo, cultured cardiomyocytes upregulate and secrete Gal-1 in response to hypoxia and proinflammatory cytokines.The aim of this study is to determine the concentration of galectin-1 in patients undergoing PCI. Materials and Methods: The current work 90 cases were collected to participate. These cases were divided into two groups, the first included 52 patientswith Myocardial Infection who underwent to elective percutaeonus coronary intervention, while the second involved 38 healthy individuals were enrolled in the present work as a control group.Sandwich-ELISA method was applied to assess human Galectin-1 concentration in the sera samples of patients and control groups. Results :When the amount of galectin-1 was tested in the sera samples of the study participants, it was found to be higher in the healthy community. When the two research groups were compared together, a highly significant difference (p<0.05) was observed.the effect of gender on the levels of serum Gal-1, the statistical Analysis of Variance (ANOVA) was applied to compare the recorded results in the study samples after classification the participants in the two groups according to their gender.The current study showed that there was a significant, statistically significant increase (p=0.000) of Gal-1 in sera samples of males undergone to elective PCI compared with healthy males, as well as the same result was observed when comparing the levels of Gal-1 in patient female samples with those in the control group (p=0.000) .While there are no statistically significant differences when comparing the two sexes within the group