Protein Network and Functional Analysis of Human Leukemia Type’s Interaction

Abstract

Comorbid diseases occurring in an individual because of two reasons. First, the common diseases genes which are the common biological factors that cause comorbid diseases Gene interactions between leukemia and lung cancer indicate a more nuanced pathogenetic process or acquired resistance to cancerogenesis, as well as the existence of an unidentified constitutional feature. Aside from the combined impact of several etiologic risk factors including smoking, genetic vulnerability, and the form and dosage of other drugs administered,Therefore, it is important building a broad protein-protein interaction network to the understanding of molecular disease mechanisms and the evolution of targeted treatments. To date, no clear nominee interaction proteins have specified and the molecular interaction events still poorly understood, A comprehensive protein-protein interaction network and a complete mechanism of interaction between human leukemia types are also lacking.So in this study, the main purpose was having been done to improve a protein-protein interaction map that exhibits the possible protein interaction and major molecular functions in myeloid - lymphoid leukemia interaction protein network. LeGenD Leukemia gene literature database was used to find all leukemia types related gens in adult and many of fusion process have been utilized to construct myeloid - lymphoid leukemia interaction network. An analyzing network represented new interactions in binding and fusion of leukemia types.These new protein interactions include 52 proteins did not have any publications on it.disease-associated genes and the major molecular functions were identified by analyzing the network in myeloid- lymphoid interaction protein.Using functional analysis of the network the most proteins in the predicted functional network have participated in signal transduction, hemostasis, Neutrophil degranulation, DNA repair, Genetic transcription pathway, Immune system and gene expression (transcription). The analysis of disease associations indicated that myeloid - lymphoid leukemia interaction disorderpossesses a significant association with diseases such as cancer, Type 2 Diabetes and pulmonary disease.More research is needed to establish the significance of newly discovered computational interactions, as well as the genetic connections between irregular myeloid-lymphoid interactions and disease.