Role of Serum Omentin-1 and Bone Metabolism Markersin Osteoporosis among Postmenopausal Women

Abstract

menopause is the most common cause of accelerated bone loss in women. Omentin-1 is secreted by the visceral adipose tissue and it isdonated in the regulation of bone metabolism in postmenopausal women which is related with decreased bone mineral density. The current study aims to investigate the role of serum omentin-1and some bone metabolism markers in osteoporosis among postmenopausal Iraqi women. This study was performedin the Rheumatology and Rehabilitation Unit, Baghdad Teaching Hospital/ Baghdad medical city, during the period from November 2019 to July 2020 with a total of 60 postmenopausal women(30 with osteoporosis and 30 without osteoporosis), their ages ranged from 52 to 62 years. They were compared with 30 healthy premenopausal women as control group, their ages ranged from 32-42 years.The postmenopausal status was determined as termination of menses for at least 1 year. All clinical and biochemical factors were measured in these individuals. There were significant decreases (p= 0.0001) in serum omentin-1 and growth differentiation factor11 levels in postmenopausal groups as compared to premenopausal. While a remarkable increase (p= 0.0001) was found in serum sclerostin level in postmenopausal group with osteoporosis as paralleled to those without osteoporosis and premenopausal group (OR 3.07, 95%CI 2.19-4.63). The significant alterations in serum omentin-1, sclerostinand growth differentiation factor11levels among postmenopausal women as compared to premenopausal group and they +were suggested thepossible role of these adipokines in bone metabolism. Moreover, in osteoporotic postmenopausal, estrogens deficiency enhance bone resorption. So, assessment of these adipokines levels could be beneficial in early detection and prevention of its unfavorable consequences of osteoporosis.