Sex impact in Oxidative Stress in Sera of Patients with Chronic obstructive pulmonary disease (COPD)

Abstract

The present study is designed to Study the effect of sex on the levels of Malondialdehyde (MDA), Ceruloplasmin (Cp), Vitamin (D3) ,Ferritin and High Sensitivity C Reactive Protein (CRP) in patients with Chronic obstructive pulmonary disease (COPD) and healthy individuals. Subjects:Serum MDA, Cp ,D3, Ferritinand CRPwere measured in ( 80COPDand 80supposed healthy subjects ) sex (40 Male , 40 Female). Results:The study resulted in a significant increase in MDA, CP, Ferritin, and h-CRP levels in females with COPD compared to healthy females(P≤0.05), and a significant decrease (vitamin D3) levels in the same group(P≤0.05). Significant increase in MDA, CP, Ferritin, and h-CRP levels(P≤0.05) in males with COPD compared to healthy controls, and decreased vitamin D3 levels in the same group.Significant increase in (MDA) and (CP) levels(P≤0.05) in infected females compared to males in the group with COPD. Significant increase in Ferritin , h-CRP levels (P≤0.05) in males with COPD compared with females with COPD. While there is no difference between males and females with COPD in terms of Vit D3 levels. Conclusion:There was effect of sex on the studied parameters .Also, there are effects of the disease state on the studied variables.