Role of Apelin-13 and Its Relationship with Hormones levels and other Parameters in Iraqi Polycystic Ovary Syndrome patients

Abstract

PCOS is an endocrino-pathy that accounts for 75 percent of infertility in women of childbearing age who are not ovulatory. Apelin is a peptidergic hormone extracted from adipose tissue.This study including the relationship of serum apelin-13 with pituitary gland hormone and they linked to the danger cardio-vascular diseases disease in the healthful and patient women with PCOS issue. This study including56 cases women with PCOS, and 34 healthy woman forming control group. The PCOS patients was subdivided by BMI into 2subgroups (the first group was excessive weight Polycystic ovary syndrome with body mass index is equal or more than 30 and the 2ed group was Normal weight Polycystic ovary syndrome PCOS body mass index is less than30). Fasting-insulin levels, HOMA-IR, FSH, LH, testosterone, GST activity, and serum AP-13 levels it was performed for all groups. PCOS Ladies appearedlower concentration of apelin-13 than control (11.21 ± 1.51 (pg/ml) versus 34.90 ± 5.98 (PG/ML), P-value=0.0001), while the glutathione s transferase activity was increase in patients of polycystic ovary syndrome and lower in healthy group (9.70 ± 1.05 (IU/L) versus 4.71 ± 0.71 (IU/L), P-value= 0.0001). APLEN-13 levels are direct proportional with BMI and HOMA IR in patients of polycystic ovary syndrome, but the glutathione s transferase activity levels no significantly correlated negatively withAPLEN-13 inpatients of polycystic ovary syndrome. In addition to, excessive weightpatients of polycystic ovary syndrome showedincreased Apelin-13levels more than Normal weight PCOS (9.42 ± 1.66 (pg/ml) versus 13.29 ± 2.61 (PG/ML), P-value=0.712),While the glutathione s transferase activity show lower in excessive weight PCO cases more than Normal weight PCOS (8.31 ± 1.27 (IU/L) versus 11.31 ± 1.71 (IU/L), P=0.167). The information recommend that Apelin-13level is negatively connected with glutathione s transferase activity in patients group. Apelin 13 does not legitimately fall into the trap of causing PCO disruption, however it may be include as an adipo-kine that influences by the BMI and effected on hormones. Increase antioxidant capacity and alsodecreasedin AP-13level may would be increase the danger of CVD in (PCOS) ladies, notwithstanding referred to hazard factors, e.g. (IR, hypertension, excessive obesity, dyslipidemia).